The fruit of an old apple cultivar were used to establish a plant cell culture line. An extract of these cultured plant cells was tested on keratinocyte progenitor cells. The extract was found to greatly increase the colony-forming efficiency, indicating an enhancement of the stem cell characteristics. The same extract, incorporated at 2 percent into a vehicle cream, was tested in a clinical trial over 4 weeks on 20 subjects. The test cream significantly reduced wrinkle depth in the crow’s feet area. The positive effect on skin smoothness could also been shown on digital photos before and after treatment.
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